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Cataract treated by Lanosterol (a neighbouring molecule of cholesterol).



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An article published it there has a few days on the site of the prestigious magazine Nature reported the results of the use of a molecule called Lanosterol as track to explore for future medical treatment of cataract, leading cause of blindness in the world (Zhao et al. Lanosterol reverses protein aggregation in philadlephia. doi:10.1038 / nature14650).
The lens is a body whose apparent simplicity of the overall geometry and appearance (a simple transparent lens) conceals a physiological challenge: be flexible (for the update in near vision, the)accommodation), transparent (to let light and focus it to the retina)... and especially to keep these properties despite the ravages of time. The presbyopia is the result of a gradual reduction in the flexibility of the crystalline lens and cataract stems from the decline of its transparency: the Crystal is no longer enough clear. The ophthalmologist has means of direct examinations (slit lamp) and objectives to evaluate the transparency of the lens.
To be transparent and let the light without too much to absorb and diffuse, a biological tissue (cornea, lens, vitreous), must have some structural properties, which have in common the regularity of the layout of the cells and the extracellular matrix which make it up. Cristalliniennes say structures are transparent to a large part of the visible light because they are made up of molecules that are a regular, almost geometric layout. These structures are usually high rigidity (ex; quartz). The water is transparent to visible light, and some biological media (ex:vitre) are very watery.
In the case due Crystalline lens , which is made up of cells rich in so-called crystalline proteins, transparency is the result of a regular and orderly arrangement of these proteins and cellular bodies, which also possess elastic properties allowing the Crystalline lens to deform, at least in subjects not having reached the age of total presbyopia. Any phenomenon of protein aggregation results in a loss of the regularity of this matrix and a reduction of transparency, with an increase in the diffusion (dispersion) luminous, from which the Visual symptoms of cataract: veil, glare, etc.
The work of the Zhao team suggests that lanosterol may reduce the protein aggregation phenomena formed within the Crystalline lens , thus increasing the transparency of it,... which is tantamount to reducing the cataract phenomenon!
Lanosterol is a molecule manufactured by "lanosterol synthase", and is involved in the cycle of cholesterol synthesis. However, Lanonsterol is not a form of cholesterol, and this molecule is amphipatic: it has a hydrophobic pole, capable of adhering to protein Frings, and a hydrophilic pole. This peculiarity confers "detergent" properties, much like soaps, and could explain its physico-chemical action at the level of the protein aggregates of Crystalline lens that it could lead to re-solubiliser.
These encouraging results have been observed on in vitro animal models, but also in dogs in vivo, which helps to nourish the hope of a therapeutic efficacy in humans, which remains to be demonstrated today, but which can be expected to will be the subject of many research work to come. To date, the only effective treatment to treat a cataract remains the surgerywhich is to remove the lens and replace it with a implant.

9 Responses to "cataracts cared for by Lanosterol (a molecule next to cholesterol)."

  1. Rochas christiane says:

    D or come ships exploded in the eyes with pain of the eyeball?
    I said that I was cataract-operated with this eye.
    Thank you very much for the answer.

  2. ME says:

    Hello doctor

    I had surgery for cataract in the right eye here is a year. I notice that my view on that eye gets blurry with also a lining sometimes on writings by far, while the operation was very well with control macular without reported problems.
    I'm worried, could you advise me? Thanks in advance
    Charles M.

  3. Dr. Damien Gatinel says:

    The leading cause of low vision after a well conducted cataract surgery is the secondary cataract, whose effects are felt beyond a variable period, usually at least a year. It corresponds to a turbidity of the capsular bag, which is kept during the surgery to insert the implant. The treatment is the capsulotomy (opening this capsule) YAG laser.

  4. Lardizabal Jean-Marie says:

    It seems that in France no experimentation is being conducted or even envisaged, currently (autumn 2017) on animals or on humans, with eye drops based on lanosterol to counter the clouding of Crystalline lens. One can wonder about the reasons for this lack of ... ... curiosity.

  5. Dr. Damien Gatinel says:

    Indeed, there were no sequels, to my knowledge, on the first results relating to the lanosterol. There is not necessarily an intention behind this, but an inquiry into why this "quiet" would be welcome, it is in all the case of an interesting track for the prevention of Cataract (or its delay).

  6. Angel Theresa says:

    I suffer from ocular rosacea diagnosed at the end of 2015 and that I control with difficulty.
    Currently, doctors tell me that cataract is there, but that with my illness
    they don't want to consider an operation.
    So I read with interest your article on the LANOSTERIOL.
    What about it? today? Has the research been successful?
    Why can't we operate?

    Can you enlighten me? Thank you

  7. Dr. Damien Gatinel says:

    To my knowledge, nothing concrete since on the lanosterol, it could be that the results published initially could not be reproduced. Rosacea is not a priori a formal contraindication to cataract surgery, except in case of important and uncontrolled anomalies of the ocular surface.

  8. Francine Boutin says:

    A product is sold on the internet, for animals. https://www.wanimo.com/fr/chiens/soin-et-hygiene-du-chien-sc3/vt-phak-gouttes-oculaires-sf8493/
    I have a cataract start and I look forward to them selling it for humans. It seems to me that if it gives results on dogs and cats, it should work for us. We are also mammals, the eyes must not be so different.
    There would not be a kind of lobby? It pays for surgeons, surgery for cataracts...

  9. Dr. Damien Gatinel says:

    No there is no lobby of surgeons, on the other hand the "anti cataract" drops that are found in the trade are they a priori absolutely useless (in all case In humans).

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